node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NP_0370A | folA | NP_0370A | NP_2922A | Uncharacterized protein. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.687 |
NP_0370A | glyA | NP_0370A | NP_2050A | Uncharacterized protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.611 |
NP_0370A | gyrB | NP_0370A | NP_3498A | Uncharacterized protein. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.777 |
folA | NP_0370A | NP_2922A | NP_0370A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Uncharacterized protein. | 0.687 |
folA | folCP | NP_2922A | NP_1478A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase. | 0.931 |
folA | folD | NP_2922A | NP_2054A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.647 |
folA | gcvT1 | NP_2922A | NP_4774A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
folA | gcvT2 | NP_2922A | NP_0436A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Homolog to glycine cleavage system protein T. | 0.925 |
folA | glyA | NP_2922A | NP_2050A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
folA | gyrB | NP_2922A | NP_3498A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.616 |
folA | hts | NP_2922A | NP_2924A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
folA | purNH | NP_2922A | NP_1662A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.932 |
folA | purU | NP_2922A | NP_5006A | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Formyltetrahydrofolate deformylase. | 0.928 |
folCP | folA | NP_1478A | NP_2922A | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.931 |
folCP | folD | NP_1478A | NP_2054A | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase. | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.833 |
folCP | glyA | NP_1478A | NP_2050A | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.762 |
folCP | hts | NP_1478A | NP_2924A | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.849 |
folCP | purNH | NP_1478A | NP_1662A | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase. | Phosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.433 |
folD | folA | NP_2054A | NP_2922A | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.647 |
folD | folCP | NP_2054A | NP_1478A | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase. | 0.833 |