Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NP_4100AADP-ribose pyrophosphatase. (231 aa)    
Predicted Functional Partners:
NP_0822A
Nicotinamide mononucleotide deamidase.
   
 0.943
NP_4102A
Uncharacterized protein.
       0.860
NP_4104A
DUF2110 family protein.
       0.828
tfeA
Transcription initiation factor TFE; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation comp [...]
       0.828
gap
Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating).
 
     0.651
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
       0.596
pgsA1
CDP-alcohol 1-archaetidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.518
agsA
Probable archaetidylglycerolphosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.518
NP_4108A
Uncharacterized protein.
       0.418
Your Current Organism:
Natronomonas pharaonis
NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160
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