STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GET3ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (341 aa)    
Predicted Functional Partners:
GET1
Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
    
 0.994
PV05_05909
Uncharacterized protein.
    
 0.990
PV05_10446
UV excision repair protein Rad23.
   
 0.968
PV05_00985
Uncharacterized protein.
    
 0.964
PV05_08354
TPR_REGION domain-containing protein.
   
 0.920
PV05_01492
LMWPc domain-containing protein.
    
 0.903
PV05_06751
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
    
 0.852
PV05_10865
t-SNARE coiled-coil homology domain-containing protein.
   
 0.830
PV05_10517
Uncharacterized protein; Belongs to the synaptobrevin family.
   
 
 0.794
PV05_09775
Ubiquitin-like protein 1.
   
 0.743
Your Current Organism:
Exophiala xenobiotica
NCBI taxonomy Id: 348802
Other names: CBS 118157, E. xenobiotica
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