node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABQ93550.1 | ABQ94488.1 | PsycPRwf_0595 | PsycPRwf_1547 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. | 0.651 |
ABQ93550.1 | cobS | PsycPRwf_0595 | PsycPRwf_0844 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.424 |
ABQ93550.1 | cobT | PsycPRwf_0595 | PsycPRwf_0843 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.461 |
ABQ93550.1 | cysG | PsycPRwf_0595 | PsycPRwf_1107 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.651 |
ABQ93793.1 | ABQ93794.1 | PsycPRwf_0841 | PsycPRwf_0842 | Hypothetical protein. | Hypothetical protein. | 0.479 |
ABQ93793.1 | ABQ93797.1 | PsycPRwf_0841 | PsycPRwf_0845 | Hypothetical protein. | PFAM: Phosphoglycerate mutase. | 0.423 |
ABQ93793.1 | cobS | PsycPRwf_0841 | PsycPRwf_0844 | Hypothetical protein. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.434 |
ABQ93793.1 | cobT | PsycPRwf_0841 | PsycPRwf_0843 | Hypothetical protein. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.434 |
ABQ93794.1 | ABQ93793.1 | PsycPRwf_0842 | PsycPRwf_0841 | Hypothetical protein. | Hypothetical protein. | 0.479 |
ABQ93794.1 | ABQ93797.1 | PsycPRwf_0842 | PsycPRwf_0845 | Hypothetical protein. | PFAM: Phosphoglycerate mutase. | 0.670 |
ABQ93794.1 | cobS | PsycPRwf_0842 | PsycPRwf_0844 | Hypothetical protein. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.689 |
ABQ93794.1 | cobT | PsycPRwf_0842 | PsycPRwf_0843 | Hypothetical protein. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.689 |
ABQ93797.1 | ABQ93793.1 | PsycPRwf_0845 | PsycPRwf_0841 | PFAM: Phosphoglycerate mutase. | Hypothetical protein. | 0.423 |
ABQ93797.1 | ABQ93794.1 | PsycPRwf_0845 | PsycPRwf_0842 | PFAM: Phosphoglycerate mutase. | Hypothetical protein. | 0.670 |
ABQ93797.1 | cobS | PsycPRwf_0845 | PsycPRwf_0844 | PFAM: Phosphoglycerate mutase. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.995 |
ABQ93797.1 | cobT | PsycPRwf_0845 | PsycPRwf_0843 | PFAM: Phosphoglycerate mutase. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.995 |
ABQ94488.1 | ABQ93550.1 | PsycPRwf_1547 | PsycPRwf_0595 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.651 |
ABQ94488.1 | cobS | PsycPRwf_1547 | PsycPRwf_0844 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.630 |
ABQ94488.1 | cobT | PsycPRwf_1547 | PsycPRwf_0843 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.665 |
ABQ94488.1 | cysG | PsycPRwf_1547 | PsycPRwf_1107 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.985 |