msbA protein (Halorhodospira halophila) - STRING interaction network

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Predicted Interactions

gene neighborhood

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msbA

Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (605 aa)

Predicted Functional Partners:

msbA-2

0.901

Hhal_0052

0.828

lpxK

0.820

Hhal_1562

0.726

Hhal_0759

0.719

Hhal_0151

0.589

wecA

0.587

Hhal_0145

0.552

Hhal_0806

0.538

dnaK

0.514

Your Current Organism:

Halorhodospira halophila

NCBI taxonomy Id: 349124
Other names: H. halophila SL1, Halorhodospira halophila DSM 244, Halorhodospira halophila SL 1, Halorhodospira halophila SL1, Halorhodospira halophila str. SL1, Halorhodospira halophila strain SL1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hhal_0052	Hhal_0145	Hhal_0052	Hhal_0145	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	PFAM: Heat shock protein 70; KEGG: sus:Acid_6320 heat shock protein 70.	0.502
Hhal_0052	Hhal_0806	Hhal_0052	Hhal_0806	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	PFAM: phosphoesterase, PA-phosphatase related; KEGG: aba:Acid345_0313 phosphoesterase, PA-phosphatase related.	0.738
Hhal_0052	dnaK	Hhal_0052	Hhal_1476	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.502
Hhal_0052	msbA	Hhal_0052	Hhal_0807	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.828
Hhal_0052	msbA-2	Hhal_0052	Hhal_1246	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.828
Hhal_0145	Hhal_0052	Hhal_0145	Hhal_0052	PFAM: Heat shock protein 70; KEGG: sus:Acid_6320 heat shock protein 70.	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	0.502
Hhal_0145	dnaK	Hhal_0145	Hhal_1476	PFAM: Heat shock protein 70; KEGG: sus:Acid_6320 heat shock protein 70.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.911
Hhal_0145	msbA	Hhal_0145	Hhal_0807	PFAM: Heat shock protein 70; KEGG: sus:Acid_6320 heat shock protein 70.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.552
Hhal_0145	msbA-2	Hhal_0145	Hhal_1246	PFAM: Heat shock protein 70; KEGG: sus:Acid_6320 heat shock protein 70.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.572
Hhal_0151	msbA	Hhal_0151	Hhal_0807	PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: aeh:Mlg_0391 ABC transporter related.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.589
Hhal_0151	msbA-2	Hhal_0151	Hhal_1246	PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: aeh:Mlg_0391 ABC transporter related.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.594
Hhal_0759	msbA	Hhal_0759	Hhal_0807	PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: aeh:Mlg_2355 ABC transporter related.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.719
Hhal_0759	msbA-2	Hhal_0759	Hhal_1246	PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: aeh:Mlg_2355 ABC transporter related.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.718
Hhal_0806	Hhal_0052	Hhal_0806	Hhal_0052	PFAM: phosphoesterase, PA-phosphatase related; KEGG: aba:Acid345_0313 phosphoesterase, PA-phosphatase related.	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	0.738
Hhal_0806	msbA	Hhal_0806	Hhal_0807	PFAM: phosphoesterase, PA-phosphatase related; KEGG: aba:Acid345_0313 phosphoesterase, PA-phosphatase related.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.538
Hhal_0806	wecA	Hhal_0806	Hhal_0808	PFAM: phosphoesterase, PA-phosphatase related; KEGG: aba:Acid345_0313 phosphoesterase, PA-phosphatase related.	Glycosyl transferase, family 4; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily.	0.478
Hhal_1562	msbA	Hhal_1562	Hhal_0807	PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: aeh:Mlg_0122 ABC transporter related.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.726
Hhal_1562	msbA-2	Hhal_1562	Hhal_1246	PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: aeh:Mlg_0122 ABC transporter related.	Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.	0.725
dnaK	Hhal_0052	Hhal_1476	Hhal_0052	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; KEGG: aeh:Mlg_1601 AMP-dependent synthetase and ligase.	0.502
dnaK	Hhal_0145	Hhal_1476	Hhal_0145	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	PFAM: Heat shock protein 70; KEGG: sus:Acid_6320 heat shock protein 70.	0.911

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.829

expected number of edges:

11

PPI enrichment p-value:

0.00667

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008654

Phospholipid biosynthetic process

8 of 37

1.88

4.02

3.63e-11

GO:0006650

Glycerophospholipid metabolic process

3 of 12

1.95

1.55

0.00079

GO:0044249

Cellular biosynthetic process

10 of 726

0.69

0.61

7.66e-05

GO:1901576

Organic substance biosynthetic process

10 of 756

0.67

0.59

9.28e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016780

Phosphotransferase activity, for other substituted phosphate groups

3 of 10

2.03

1.26

0.0037

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23500459

(2013) Bacterial lipids: metabolism and membrane homeostasis.

4 of 16

1.95

1.74

0.00030

PMID:32887610

(2020) Inducible intracellular membranes: molecular aspects and emerging applications.

3 of 7

2.18

1.45

0.0018

PMID:21255114

(2011) Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments.

2 of 2

2.55

0.87

0.0265

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1421

Glycerophospholipid metabolism

7 of 13

2.28

5.18

8.75e-12

CL:1373

Fatty acid biosynthesis, and Glycerophospholipid metabolism

8 of 37

1.88

4.15

1.23e-11

CL:1423

Glycerophospholipid metabolism

4 of 5

2.45

3.13

1.00e-06

CL:1437

Alditol phosphate metabolic process, and Phospholipid biosynthesis

2 of 5

2.15

0.84

0.0281

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp00564

Glycerophospholipid metabolism

7 of 17

2.16

5.04

4.64e-12

rsp00561

Glycerolipid metabolism

2 of 11

1.81

0.93

0.0154

rsp01110

Biosynthesis of secondary metabolites

8 of 346

0.91

0.9

3.09e-05

rsp01100

Metabolic pathways

8 of 774

0.56

0.4

0.0087

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0594

Phospholipid biosynthesis

5 of 6

2.47

4.18

6.87e-09

KW-0444

Lipid biosynthesis

6 of 25

1.93

3.44

8.27e-09

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