| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Hhal_0172 | tatA | Hhal_0172 | Hhal_1089 | Sec-independent protein translocase TatD; PFAM: TatD-related deoxyribonuclease; KEGG: aeh:Mlg_1579 TatD-related deoxyribonuclease. | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.660 |
| Hhal_0172 | tatB | Hhal_0172 | Hhal_1088 | Sec-independent protein translocase TatD; PFAM: TatD-related deoxyribonuclease; KEGG: aeh:Mlg_1579 TatD-related deoxyribonuclease. | Twin-arginine translocation protein, TatB subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.634 |
| Hhal_0172 | tatC | Hhal_0172 | Hhal_1087 | Sec-independent protein translocase TatD; PFAM: TatD-related deoxyribonuclease; KEGG: aeh:Mlg_1579 TatD-related deoxyribonuclease. | Sec-independent protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.657 |
| guaA | hisA | Hhal_1681 | Hhal_1092 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.736 |
| guaA | hisB | Hhal_1681 | Hhal_1094 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: tcx:Tcr_1966 imidazoleglycerol-phosphate dehydratase. | 0.406 |
| guaA | hisH | Hhal_1681 | Hhal_1093 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.499 |
| guaA | tatA | Hhal_1681 | Hhal_1089 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.927 |
| guaA | tatB | Hhal_1681 | Hhal_1088 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Twin-arginine translocation protein, TatB subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.927 |
| hisA | guaA | Hhal_1092 | Hhal_1681 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.736 |
| hisA | hisB | Hhal_1092 | Hhal_1094 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: tcx:Tcr_1966 imidazoleglycerol-phosphate dehydratase. | 0.997 |
| hisA | hisE | Hhal_1092 | Hhal_1090 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: aeh:Mlg_2613 phosphoribosyl-ATP pyrophosphohydrolase. | 0.995 |
| hisA | hisF | Hhal_1092 | Hhal_1091 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisA | hisH | Hhal_1092 | Hhal_1093 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | tatA | Hhal_1092 | Hhal_1089 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.746 |
| hisA | tatB | Hhal_1092 | Hhal_1088 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Twin-arginine translocation protein, TatB subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.668 |
| hisA | tatC | Hhal_1092 | Hhal_1087 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Sec-independent protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.653 |
| hisB | guaA | Hhal_1094 | Hhal_1681 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: tcx:Tcr_1966 imidazoleglycerol-phosphate dehydratase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.406 |
| hisB | hisA | Hhal_1094 | Hhal_1092 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: tcx:Tcr_1966 imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: aeh:Mlg_2615 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.997 |
| hisB | hisE | Hhal_1094 | Hhal_1090 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: tcx:Tcr_1966 imidazoleglycerol-phosphate dehydratase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: aeh:Mlg_2613 phosphoribosyl-ATP pyrophosphohydrolase. | 0.994 |
| hisB | hisF | Hhal_1094 | Hhal_1091 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: tcx:Tcr_1966 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |