node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hhal_1026 | Hhal_1027 | Hhal_1026 | Hhal_1027 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | 0.988 |
Hhal_1026 | Hhal_1350 | Hhal_1026 | Hhal_1350 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: mca:MCA2299 CbiX protein. | 0.407 |
Hhal_1026 | cysC-2 | Hhal_1026 | Hhal_2354 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.588 |
Hhal_1026 | cysG1 | Hhal_1026 | Hhal_1343 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.994 |
Hhal_1026 | cysG2 | Hhal_1026 | Hhal_1933 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.996 |
Hhal_1026 | hemC | Hhal_1026 | Hhal_1025 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Hhal_1026 | hemE | Hhal_1026 | Hhal_1058 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.940 |
Hhal_1027 | Hhal_1026 | Hhal_1027 | Hhal_1026 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.988 |
Hhal_1027 | Hhal_1347 | Hhal_1027 | Hhal_1347 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dar:Daro_1688 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.900 |
Hhal_1027 | cysG1 | Hhal_1027 | Hhal_1343 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
Hhal_1027 | cysG2 | Hhal_1027 | Hhal_1933 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
Hhal_1027 | hemC | Hhal_1027 | Hhal_1025 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.866 |
Hhal_1027 | hemE | Hhal_1027 | Hhal_1058 | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.903 |
Hhal_1347 | Hhal_1027 | Hhal_1347 | Hhal_1027 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dar:Daro_1688 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: protein of unknown function DUF513, hemX; KEGG: aeh:Mlg_2668 protein of unknown function DUF513, HemX. | 0.900 |
Hhal_1347 | Hhal_1350 | Hhal_1347 | Hhal_1350 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dar:Daro_1688 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: mca:MCA2299 CbiX protein. | 0.996 |
Hhal_1347 | cysG1 | Hhal_1347 | Hhal_1343 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dar:Daro_1688 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.989 |
Hhal_1347 | cysG2 | Hhal_1347 | Hhal_1933 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dar:Daro_1688 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.956 |
Hhal_1350 | Hhal_1026 | Hhal_1350 | Hhal_1026 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: mca:MCA2299 CbiX protein. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.407 |
Hhal_1350 | Hhal_1347 | Hhal_1350 | Hhal_1347 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: mca:MCA2299 CbiX protein. | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dar:Daro_1688 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.996 |
Hhal_1350 | cysC-2 | Hhal_1350 | Hhal_2354 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: mca:MCA2299 CbiX protein. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.559 |