| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Hhal_0366 | Hhal_2001 | Hhal_0366 | Hhal_2001 | KEGG: mgm:Mmc1_3409 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.576 |
| Hhal_0366 | polA | Hhal_0366 | Hhal_2421 | KEGG: mgm:Mmc1_3409 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.708 |
| Hhal_1799 | Hhal_2001 | Hhal_1799 | Hhal_2001 | PFAM: Colicin V production protein; KEGG: aeh:Mlg_1241 colicin V production protein. | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.559 |
| Hhal_1799 | purD | Hhal_1799 | Hhal_1999 | PFAM: Colicin V production protein; KEGG: aeh:Mlg_1241 colicin V production protein. | KEGG: aeh:Mlg_0612 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. | 0.589 |
| Hhal_1799 | purH | Hhal_1799 | Hhal_2000 | PFAM: Colicin V production protein; KEGG: aeh:Mlg_1241 colicin V production protein. | IMP cyclohydrolase; KEGG: aeh:Mlg_0611 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.678 |
| Hhal_2001 | Hhal_0366 | Hhal_2001 | Hhal_0366 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | KEGG: mgm:Mmc1_3409 multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. | 0.576 |
| Hhal_2001 | Hhal_1799 | Hhal_2001 | Hhal_1799 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | PFAM: Colicin V production protein; KEGG: aeh:Mlg_1241 colicin V production protein. | 0.559 |
| Hhal_2001 | Hhal_2002 | Hhal_2001 | Hhal_2002 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | TIGRFAM: MJ0042 family finger-like protein; KEGG: bpe:BP2994 possible membrane protein. | 0.677 |
| Hhal_2001 | dusA | Hhal_2001 | Hhal_0110 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | tRNA-U16,U17-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | 0.545 |
| Hhal_2001 | polA | Hhal_2001 | Hhal_2421 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.576 |
| Hhal_2001 | prmA | Hhal_2001 | Hhal_2003 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | [LSU ribosomal protein L11P]-lysine N-methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 0.736 |
| Hhal_2001 | purD | Hhal_2001 | Hhal_1999 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | KEGG: aeh:Mlg_0612 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. | 0.747 |
| Hhal_2001 | purH | Hhal_2001 | Hhal_2000 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | IMP cyclohydrolase; KEGG: aeh:Mlg_0611 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.801 |
| Hhal_2001 | recO | Hhal_2001 | Hhal_0032 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.552 |
| Hhal_2001 | rpsJ | Hhal_2001 | Hhal_0859 | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | 0.559 |
| Hhal_2002 | Hhal_2001 | Hhal_2002 | Hhal_2001 | TIGRFAM: MJ0042 family finger-like protein; KEGG: bpe:BP2994 possible membrane protein. | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.677 |
| Hhal_2002 | prmA | Hhal_2002 | Hhal_2003 | TIGRFAM: MJ0042 family finger-like protein; KEGG: bpe:BP2994 possible membrane protein. | [LSU ribosomal protein L11P]-lysine N-methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 0.748 |
| Hhal_2002 | purD | Hhal_2002 | Hhal_1999 | TIGRFAM: MJ0042 family finger-like protein; KEGG: bpe:BP2994 possible membrane protein. | KEGG: aeh:Mlg_0612 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. | 0.614 |
| Hhal_2002 | purH | Hhal_2002 | Hhal_2000 | TIGRFAM: MJ0042 family finger-like protein; KEGG: bpe:BP2994 possible membrane protein. | IMP cyclohydrolase; KEGG: aeh:Mlg_0611 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.646 |
| dusA | Hhal_2001 | Hhal_0110 | Hhal_2001 | tRNA-U16,U17-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | Transcriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.545 |