Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Dred_0686RNA polymerase, sigma 29 subunit, SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (241 aa)    
Predicted Functional Partners:
Dred_0685
Sporulation factor SpoIIGA, Unknown type peptidase, MEROPS family U04; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
 
  
 0.926
Dred_0688
PFAM: PRC-barrel domain protein; KEGG: mta:Moth_0855 PRC-barrel.
 
     0.872
Dred_0113
TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein; KEGG: chy:CHY_0202 stage V sporulation protein T.
  
    0.810
Dred_3145
TIGRFAM: regulatory protein, DeoR; KEGG: chy:CHY_2534 stage III sporulation protein D.
  
    0.810
Dred_2621
Hypothetical protein; KEGG: mta:Moth_1505 response regulator receiver domain protein (CheY-like).
  
   
 0.806
Dred_1086
Response regulator receiver protein; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.799
Dred_0458
KEGG: tte:TTE2552 pro-sigma-E processing factor spoIIR.
 
     0.796
Dred_1163
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
    0.784
Dred_1107
PFAM: Stage V sporulation AD family protein; KEGG: mta:Moth_1375 stage V sporulation AD.
  
     0.775
Dred_1085
SpoIVB peptidase, Serine peptidase, MEROPS family S55; PFAM: peptidase S55, SpoIVB; KEGG: mta:Moth_1506 peptidase S55, SpoIVB.
  
     0.774
Your Current Organism:
Desulfotomaculum reducens
NCBI taxonomy Id: 349161
Other names: D. reducens MI-1, Desulfotomaculum reducens MI-1, Desulfotomaculum reducens str. MI-1, Desulfotomaculum reducens strain MI-1
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