Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Dred_1908PFAM: Phosphoglycerate mutase; KEGG: mta:Moth_1105 phosphoglycerate/bisphosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (208 aa)    
Predicted Functional Partners:
Dred_0097
L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: chy:CHY_0191 threonine dehydratase.
  
  
  0.920
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.918
Dred_1252
KEGG: gka:GK1184 L-serine dehydratase (L-serine deaminase) beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: amino acid-binding ACT domain protein; serine dehydratase beta chain.
  
 
  0.907
Dred_1253
TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain; KEGG: bld:BLi01807 probable L-serine dehydratase (alpha chain); RBL04042.
  
 
  0.907
trpB
Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.900
trpB-2
Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
Dred_1744
TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: dsy:DSY1871 hypothetical protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
cobS
Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
 
 0.862
Dred_0192
TIGRFAM: serine O-acetyltransferase; KEGG: chy:CHY_2339 serine acetyltransferase.
     
 0.805
Your Current Organism:
Desulfotomaculum reducens
NCBI taxonomy Id: 349161
Other names: D. reducens MI-1, Desulfotomaculum reducens MI-1, Desulfotomaculum reducens str. MI-1, Desulfotomaculum reducens strain MI-1
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