Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Dred_2002PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mta:Moth_1488 ATP dependent DNA ligase, central. (316 aa)    
Predicted Functional Partners:
Dred_1986
PFAM: DNA primase, small subunit; KEGG: mta:Moth_2082 hypothetical protein.
   
 0.985
Dred_1180
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: sat:SYN_00429 exodeoxyribonuclease III.
 
 
 0.972
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.969
Dred_1634
PFAM: PHP C-terminal domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; KEGG: mtp:Mthe_1315 PHP C-terminal domain protein.
  
 0.959
Dred_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.956
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.945
Dred_0705
PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: mta:Moth_1187 RNA-metabolising metallo-beta-lactamase.
  
 0.572
dinG
DNA polymerase III, epsilon subunit; 3'-5' exonuclease.
   
 
 0.534
Dred_2571
PFAM: metallophosphoesterase; KEGG: syf:Synpcc7942_1252 DNA repair protein RAD32-like.
   
 0.532
Dred_1737
KEGG: mgm:Mmc1_1358 hypothetical protein.
   
 0.505
Your Current Organism:
Desulfotomaculum reducens
NCBI taxonomy Id: 349161
Other names: D. reducens MI-1, Desulfotomaculum reducens MI-1, Desulfotomaculum reducens str. MI-1, Desulfotomaculum reducens strain MI-1
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