hypA protein (Acidiphilium cryptum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

hypA

Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)

Predicted Functional Partners:

Acry_0330

0.992

Acry_0337

0.984

Acry_0335

0.950

Acry_0338

0.936

Acry_0333

0.927

Acry_0336

0.923

Acry_0334

0.917

Acry_0329

0.877

Acry_0327

0.876

Acry_0328

0.853

Your Current Organism:

Acidiphilium cryptum

NCBI taxonomy Id: 349163
Other names: A. cryptum JF-5, Acidiphilium cryptum JF-5, Acidiphilium cryptum str. JF-5, Acidiphilium cryptum strain JF-5, Acidiphilum cryptum JF-5

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acry_0327	Acry_0328	Acry_0327	Acry_0328	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	0.973
Acry_0327	Acry_0329	Acry_0327	Acry_0329	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	0.998
Acry_0327	Acry_0330	Acry_0327	Acry_0330	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein, P47K.	0.968
Acry_0327	Acry_0335	Acry_0327	Acry_0335	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	Hydrogenase 1 maturation peptidase HyaD, Aspartic peptidase, MEROPS family A31; TIGRFAM: hydrogenase maturation protease; hydrogenase expression/formation protein; PFAM: peptidase M52, hydrogen uptake protein.	0.569
Acry_0327	Acry_0337	Acry_0327	Acry_0337	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	PFAM: nickel-dependent hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.713
Acry_0327	Acry_0338	Acry_0327	Acry_0338	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit; Nickel-iron dehydrogenase small subunit, N-terminal domain protein.	0.573
Acry_0327	hypA	Acry_0327	Acry_0331	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.876
Acry_0328	Acry_0327	Acry_0328	Acry_0327	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	0.973
Acry_0328	Acry_0329	Acry_0328	Acry_0329	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	0.995
Acry_0328	Acry_0330	Acry_0328	Acry_0330	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein, P47K.	0.867
Acry_0328	Acry_0335	Acry_0328	Acry_0335	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase 1 maturation peptidase HyaD, Aspartic peptidase, MEROPS family A31; TIGRFAM: hydrogenase maturation protease; hydrogenase expression/formation protein; PFAM: peptidase M52, hydrogen uptake protein.	0.543
Acry_0328	Acry_0337	Acry_0328	Acry_0337	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	PFAM: nickel-dependent hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.670
Acry_0328	Acry_0338	Acry_0328	Acry_0338	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit; Nickel-iron dehydrogenase small subunit, N-terminal domain protein.	0.590
Acry_0328	hypA	Acry_0328	Acry_0331	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.853
Acry_0329	Acry_0327	Acry_0329	Acry_0327	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	PFAM: hydrogenase formation HypD protein; Belongs to the HypD family.	0.998
Acry_0329	Acry_0328	Acry_0329	Acry_0328	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.	0.995
Acry_0329	Acry_0330	Acry_0329	Acry_0330	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein, P47K.	0.886
Acry_0329	Acry_0335	Acry_0329	Acry_0335	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	Hydrogenase 1 maturation peptidase HyaD, Aspartic peptidase, MEROPS family A31; TIGRFAM: hydrogenase maturation protease; hydrogenase expression/formation protein; PFAM: peptidase M52, hydrogen uptake protein.	0.605
Acry_0329	Acry_0337	Acry_0329	Acry_0337	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	PFAM: nickel-dependent hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.725
Acry_0329	Acry_0338	Acry_0329	Acry_0338	TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.	TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit; Nickel-iron dehydrogenase small subunit, N-terminal domain protein.	0.637

page 1 of 5

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About