node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCH_00723 | HCH_00724 | HCH_00723 | HCH_00724 | Short-chain alcohol dehydrogenase-like protein; COG1028. | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.598 |
HCH_00724 | HCH_00723 | HCH_00724 | HCH_00723 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Short-chain alcohol dehydrogenase-like protein; COG1028. | 0.598 |
HCH_00724 | metH | HCH_00724 | HCH_02542 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.547 |
HCH_00724 | psuG | HCH_00724 | HCH_01392 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Uncharacterized enzyme involved in pigment biosynthesis; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. | 0.609 |
HCH_00724 | rplB | HCH_00724 | HCH_06214 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.565 |
HCH_00724 | rplF | HCH_00724 | HCH_06201 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.596 |
HCH_00724 | rplP | HCH_00724 | HCH_06210 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.537 |
HCH_00724 | serC | HCH_00724 | HCH_04982 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.841 |
HCH_00724 | thrA | HCH_00724 | HCH_01779 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Homoserine dehydrogenase; COG0460. | 0.556 |
HCH_00724 | thrC | HCH_00724 | HCH_01780 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Threonine synthase; TIGRFAMsMatches:TIGR00260. | 0.556 |
HCH_00724 | udk | HCH_00724 | HCH_00098 | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Uridine kinase; TIGRFAMsMatches:TIGR00235. | 0.581 |
metH | HCH_00724 | HCH_02542 | HCH_00724 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.547 |
metH | thrA | HCH_02542 | HCH_01779 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase; COG0460. | 0.949 |
metH | thrC | HCH_02542 | HCH_01780 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Threonine synthase; TIGRFAMsMatches:TIGR00260. | 0.559 |
psuG | HCH_00724 | HCH_01392 | HCH_00724 | Uncharacterized enzyme involved in pigment biosynthesis; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.609 |
rplB | HCH_00724 | HCH_06214 | HCH_00724 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.565 |
rplB | rplF | HCH_06214 | HCH_06201 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.997 |
rplB | rplP | HCH_06214 | HCH_06210 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.999 |
rplF | HCH_00724 | HCH_06201 | HCH_00724 | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | Phosphoglycerate dehydrogenase and related dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.596 |
rplF | rplB | HCH_06201 | HCH_06214 | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.997 |