node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCH_00409 | HCH_00564 | HCH_00409 | HCH_00564 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Predicted hydrolase (HAD superfamily); COG1011. | 0.912 |
HCH_00409 | HCH_02315 | HCH_00409 | HCH_02315 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | 0.927 |
HCH_00409 | dut | HCH_00409 | HCH_01022 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
HCH_00409 | surE | HCH_00409 | HCH_01872 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
HCH_00409 | thiA | HCH_00409 | HCH_05857 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.908 |
HCH_00409 | tmk | HCH_00409 | HCH_02148 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.916 |
HCH_00564 | HCH_00409 | HCH_00564 | HCH_00409 | Predicted hydrolase (HAD superfamily); COG1011. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | 0.912 |
HCH_00564 | HCH_02315 | HCH_00564 | HCH_02315 | Predicted hydrolase (HAD superfamily); COG1011. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | 0.912 |
HCH_00564 | dut | HCH_00564 | HCH_01022 | Predicted hydrolase (HAD superfamily); COG1011. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.903 |
HCH_00564 | surE | HCH_00564 | HCH_01872 | Predicted hydrolase (HAD superfamily); COG1011. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.918 |
HCH_00564 | thiA | HCH_00564 | HCH_05857 | Predicted hydrolase (HAD superfamily); COG1011. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.910 |
HCH_00564 | tmk | HCH_00564 | HCH_02148 | Predicted hydrolase (HAD superfamily); COG1011. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.907 |
HCH_02315 | HCH_00409 | HCH_02315 | HCH_00409 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | 0.927 |
HCH_02315 | HCH_00564 | HCH_02315 | HCH_00564 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Predicted hydrolase (HAD superfamily); COG1011. | 0.912 |
HCH_02315 | dut | HCH_02315 | HCH_01022 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
HCH_02315 | surE | HCH_02315 | HCH_01872 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
HCH_02315 | thiA | HCH_02315 | HCH_05857 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.908 |
HCH_02315 | tmk | HCH_02315 | HCH_02148 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; COG0737; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.916 |
coaBC | dut | HCH_01021 | HCH_01022 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.995 |
coaBC | slmA | HCH_01021 | HCH_06098 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.732 |