STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; COG0166.
  
 0.990
fba
Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 
 0.954
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.937
fbp
Fructose-1,6-bisphosphatase; COG0158.
    
 0.936
HCH_02412
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; TIGRFAMsMatches:TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.931
pyk
Pyruvate kinase; TIGRFAMsMatches:TIGR01064; Belongs to the pyruvate kinase family.
 
 
 0.925
tal1
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
    
 0.923
tal2
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily.
    
 0.923
HCH_06077
Sugar kinase, ribokinase family; COG0524.
  
 
 0.914
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
  
  
 0.903
Your Current Organism:
Hahella chejuensis
NCBI taxonomy Id: 349521
Other names: H. chejuensis KCTC 2396, Hahella chejuensis KCTC 2396, Hahella chejuensis str. KCTC 2396, Hahella chejuensis strain KCTC 2396
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