node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mvan_0794 | Mvan_1202 | Mvan_0794 | Mvan_1202 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | 0.964 |
Mvan_0794 | Mvan_2290 | Mvan_0794 | Mvan_2290 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: bxe:Bxe_B1666 dehydrogenase; Belongs to the GcvT family. | 0.678 |
Mvan_0794 | gcvH | Mvan_0794 | Mvan_3136 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.981 |
Mvan_0794 | gcvP | Mvan_0794 | Mvan_3131 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.953 |
Mvan_0794 | gcvT | Mvan_0794 | Mvan_3574 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.972 |
Mvan_0794 | glyA | Mvan_0794 | Mvan_4656 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
Mvan_0794 | kgd | Mvan_0794 | Mvan_4477 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | 2-oxoglutarate dehydrogenase E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate ( [...] | 0.999 |
Mvan_0794 | prs | Mvan_0794 | Mvan_4783 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.757 |
Mvan_1202 | Mvan_0794 | Mvan_1202 | Mvan_0794 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. | 0.964 |
Mvan_1202 | Mvan_1619 | Mvan_1202 | Mvan_1619 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: mmc:Mmcs_1249 pyridine nucleotide-disulphide oxidoreductase dimerisation region. | 0.653 |
Mvan_1202 | Mvan_2290 | Mvan_1202 | Mvan_2290 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: bxe:Bxe_B1666 dehydrogenase; Belongs to the GcvT family. | 0.580 |
Mvan_1202 | gcvH | Mvan_1202 | Mvan_3136 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
Mvan_1202 | gcvP | Mvan_1202 | Mvan_3131 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.997 |
Mvan_1202 | gcvT | Mvan_1202 | Mvan_3574 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.921 |
Mvan_1202 | glyA | Mvan_1202 | Mvan_4656 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
Mvan_1202 | kgd | Mvan_1202 | Mvan_4477 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | 2-oxoglutarate dehydrogenase E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate ( [...] | 0.862 |
Mvan_1202 | prs | Mvan_1202 | Mvan_4783 | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.539 |
Mvan_1619 | Mvan_1202 | Mvan_1619 | Mvan_1202 | Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: mmc:Mmcs_1249 pyridine nucleotide-disulphide oxidoreductase dimerisation region. | PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. | 0.653 |
Mvan_1619 | Mvan_2290 | Mvan_1619 | Mvan_2290 | Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: mmc:Mmcs_1249 pyridine nucleotide-disulphide oxidoreductase dimerisation region. | PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: bxe:Bxe_B1666 dehydrogenase; Belongs to the GcvT family. | 0.678 |
Mvan_1619 | gcvH | Mvan_1619 | Mvan_3136 | Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: mmc:Mmcs_1249 pyridine nucleotide-disulphide oxidoreductase dimerisation region. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.853 |