STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
disAProtein of unknown function DUF147; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. (358 aa)    
Predicted Functional Partners:
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.943
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins.
  
    0.698
Clos_0454
PFAM: UvrB/UvrC protein; KEGG: mta:Moth_0160 UvrB/UvrC protein.
  
    0.692
Clos_0456
PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: tte:TTE2327 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family.
  
    0.680
Clos_0461
PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc; KEGG: cdf:CD0029 hypothetical protein.
  
  
 0.600
Clos_1433
PFAM: Stage II sporulation E family protein; Protein phosphatase 2C-like; SMART: protein phosphatase 2C domain protein; KEGG: tte:TTE1501 protein serine/threonine phosphatases.
      
 0.590
nagB
Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
       0.461
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
    0.451
Clos_0549
TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; KEGG: tte:TTE0604 Superfamily I DNA and RNA helicases.
   
    0.418
Clos_1817
PFAM: UvrD/REP helicase; KEGG: cdf:CD0749 putative ATP-dependent DNA helicase.
   
    0.418
Your Current Organism:
Alkaliphilus oremlandii
NCBI taxonomy Id: 350688
Other names: A. oremlandii OhILAs, Alkaliphilus oremlandii OhILAs, Alkaliphilus oremlandii str. OhILAs, Alkaliphilus oremlandii strain OhILAs, Clostridium oremlandii OhILAs, Clostridium sp. OhILAs
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