node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clos_0558 | murI | Clos_0558 | Clos_2068 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.934 |
Clos_2066 | Clos_2067 | Clos_2066 | Clos_2067 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: btl:BALH_1927 ABC transporter, ATP-binding protein. | KEGG: cac:CAC0953 hypothetical protein. | 0.686 |
Clos_2066 | murI | Clos_2066 | Clos_2068 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: btl:BALH_1927 ABC transporter, ATP-binding protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.690 |
Clos_2067 | Clos_2066 | Clos_2067 | Clos_2066 | KEGG: cac:CAC0953 hypothetical protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: btl:BALH_1927 ABC transporter, ATP-binding protein. | 0.686 |
Clos_2067 | murI | Clos_2067 | Clos_2068 | KEGG: cac:CAC0953 hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.762 |
glsA | murD | Clos_2008 | Clos_1377 | PFAM: glutaminase; KEGG: ctc:CTC00566 glutaminase; Belongs to the glutaminase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.903 |
glsA | murI | Clos_2008 | Clos_2068 | PFAM: glutaminase; KEGG: ctc:CTC00566 glutaminase; Belongs to the glutaminase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.943 |
glyA | murI | Clos_1700 | Clos_2068 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.653 |
murB | murC | Clos_0573 | Clos_2649 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.999 |
murB | murD | Clos_0573 | Clos_1377 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.905 |
murB | murF | Clos_0573 | Clos_1375 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.891 |
murB | murG | Clos_0573 | Clos_1379 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.903 |
murB | murI | Clos_0573 | Clos_2068 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.726 |
murC | murB | Clos_2649 | Clos_0573 | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.999 |
murC | murD | Clos_2649 | Clos_1377 | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.991 |
murC | murF | Clos_2649 | Clos_1375 | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.919 |
murC | murG | Clos_2649 | Clos_1379 | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.963 |
murC | murI | Clos_2649 | Clos_2068 | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.711 |
murD | glsA | Clos_1377 | Clos_2008 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | PFAM: glutaminase; KEGG: ctc:CTC00566 glutaminase; Belongs to the glutaminase family. | 0.903 |
murD | murB | Clos_1377 | Clos_0573 | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.905 |