node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clos_2189 | Clos_2721 | Clos_2189 | Clos_2721 | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | PFAM: Heavy metal transport/detoxification protein; KEGG: cth:Cthe_1849 heavy metal transport/detoxification protein. | 0.435 |
Clos_2189 | pyrC | Clos_2189 | Clos_2194 | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.421 |
Clos_2189 | pyrD | Clos_2189 | Clos_2191 | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.449 |
Clos_2189 | pyrE | Clos_2189 | Clos_2190 | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.457 |
Clos_2189 | pyrF | Clos_2189 | Clos_2193 | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: cth:Cthe_0951 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.449 |
Clos_2189 | pyrK | Clos_2189 | Clos_2192 | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.449 |
Clos_2721 | Clos_2189 | Clos_2721 | Clos_2189 | PFAM: Heavy metal transport/detoxification protein; KEGG: cth:Cthe_1849 heavy metal transport/detoxification protein. | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | 0.435 |
Clos_2721 | pyrE | Clos_2721 | Clos_2190 | PFAM: Heavy metal transport/detoxification protein; KEGG: cth:Cthe_1849 heavy metal transport/detoxification protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.463 |
pyrC | Clos_2189 | Clos_2194 | Clos_2189 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | 0.421 |
pyrC | pyrD | Clos_2194 | Clos_2191 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.999 |
pyrC | pyrE | Clos_2194 | Clos_2190 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.981 |
pyrC | pyrF | Clos_2194 | Clos_2193 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: cth:Cthe_0951 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.966 |
pyrC | pyrK | Clos_2194 | Clos_2192 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.998 |
pyrD | Clos_2189 | Clos_2191 | Clos_2189 | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | 0.449 |
pyrD | pyrC | Clos_2191 | Clos_2194 | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrD | pyrE | Clos_2191 | Clos_2190 | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.999 |
pyrD | pyrF | Clos_2191 | Clos_2193 | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: cth:Cthe_0951 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.985 |
pyrD | pyrK | Clos_2191 | Clos_2192 | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.999 |
pyrE | Clos_2189 | Clos_2190 | Clos_2189 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | PFAM: protein of unknown function DUF45; KEGG: bcz:BCZK0309 conserved hypothetical protein; possible zinc metalloprotease. | 0.457 |
pyrE | Clos_2721 | Clos_2190 | Clos_2721 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | PFAM: Heavy metal transport/detoxification protein; KEGG: cth:Cthe_1849 heavy metal transport/detoxification protein. | 0.463 |