node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RCH33_120 | RCH33_526 | RCH33_120 | RCH33_526 | Phosphoribosylformylglycinamidine cyclo-ligase. | Amidophosphoribosyltransferase. | 0.972 |
RCH33_120 | folD | RCH33_120 | RCH33_1853 | Phosphoribosylformylglycinamidine cyclo-ligase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.625 |
RCH33_120 | glyA | RCH33_120 | RCH33_438 | Phosphoribosylformylglycinamidine cyclo-ligase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.655 |
RCH33_120 | purC | RCH33_120 | RCH33_1058 | Phosphoribosylformylglycinamidine cyclo-ligase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.972 |
RCH33_120 | purD | RCH33_120 | RCH33_865 | Phosphoribosylformylglycinamidine cyclo-ligase. | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.967 |
RCH33_120 | purE | RCH33_120 | RCH33_3094 | Phosphoribosylformylglycinamidine cyclo-ligase. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.960 |
RCH33_120 | purH | RCH33_120 | RCH33_2522 | Phosphoribosylformylglycinamidine cyclo-ligase. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.908 |
RCH33_120 | purL | RCH33_120 | RCH33_267 | Phosphoribosylformylglycinamidine cyclo-ligase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.999 |
RCH33_120 | purN | RCH33_120 | RCH33_522 | Phosphoribosylformylglycinamidine cyclo-ligase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.929 |
RCH33_526 | RCH33_120 | RCH33_526 | RCH33_120 | Amidophosphoribosyltransferase. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.972 |
RCH33_526 | folD | RCH33_526 | RCH33_1853 | Amidophosphoribosyltransferase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.585 |
RCH33_526 | glyA | RCH33_526 | RCH33_438 | Amidophosphoribosyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.789 |
RCH33_526 | purC | RCH33_526 | RCH33_1058 | Amidophosphoribosyltransferase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.962 |
RCH33_526 | purD | RCH33_526 | RCH33_865 | Amidophosphoribosyltransferase. | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.998 |
RCH33_526 | purE | RCH33_526 | RCH33_3094 | Amidophosphoribosyltransferase. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.936 |
RCH33_526 | purH | RCH33_526 | RCH33_2522 | Amidophosphoribosyltransferase. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.964 |
RCH33_526 | purL | RCH33_526 | RCH33_267 | Amidophosphoribosyltransferase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.999 |
RCH33_526 | purN | RCH33_526 | RCH33_522 | Amidophosphoribosyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
folD | RCH33_120 | RCH33_1853 | RCH33_120 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.625 |
folD | RCH33_526 | RCH33_1853 | RCH33_526 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Amidophosphoribosyltransferase. | 0.585 |