node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LRC263 | RCIX407 | LRC263 | RCIX407 | Hypothetical protein. | Conserved hypothetical protein. | 0.922 |
LRC263 | fen | LRC263 | RCIX607 | Hypothetical protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.653 |
LRC263 | mcm | LRC263 | RCIX2243 | Hypothetical protein. | Putative DNA replication licensing factor; Belongs to the MCM family. | 0.922 |
LRC263 | pcn | LRC263 | RCIX2293 | Hypothetical protein. | Putative DNA polymerase sliding clamp (proliferating cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.974 |
LRC263 | polB-1 | LRC263 | LRC154 | Hypothetical protein. | DNA-directed DNA polymerase B. | 0.842 |
LRC263 | polB-4 | LRC263 | RRC383 | Hypothetical protein. | DNA-directed DNA polymerase B. | 0.734 |
LRC263 | priA | LRC263 | LRC299 | Hypothetical protein. | DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.834 |
LRC263 | rfcS | LRC263 | LRC39 | Hypothetical protein. | Replication factor C (clamp loader), small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.883 |
RCIX407 | LRC263 | RCIX407 | LRC263 | Conserved hypothetical protein. | Hypothetical protein. | 0.922 |
RCIX407 | fen | RCIX407 | RCIX607 | Conserved hypothetical protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.653 |
RCIX407 | mcm | RCIX407 | RCIX2243 | Conserved hypothetical protein. | Putative DNA replication licensing factor; Belongs to the MCM family. | 0.935 |
RCIX407 | pcn | RCIX407 | RCIX2293 | Conserved hypothetical protein. | Putative DNA polymerase sliding clamp (proliferating cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.972 |
RCIX407 | polB-1 | RCIX407 | LRC154 | Conserved hypothetical protein. | DNA-directed DNA polymerase B. | 0.770 |
RCIX407 | polB-4 | RCIX407 | RRC383 | Conserved hypothetical protein. | DNA-directed DNA polymerase B. | 0.734 |
RCIX407 | priA | RCIX407 | LRC299 | Conserved hypothetical protein. | DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.819 |
RCIX407 | rfcS | RCIX407 | LRC39 | Conserved hypothetical protein. | Replication factor C (clamp loader), small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.867 |
fen | LRC263 | RCIX607 | LRC263 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Hypothetical protein. | 0.653 |
fen | RCIX407 | RCIX607 | RCIX407 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Conserved hypothetical protein. | 0.653 |
fen | mcm | RCIX607 | RCIX2243 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Putative DNA replication licensing factor; Belongs to the MCM family. | 0.832 |
fen | pcn | RCIX607 | RCIX2293 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Putative DNA polymerase sliding clamp (proliferating cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.995 |