Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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pan-126S proteasome regulatory subunit (proteasome-activating nucleotidase); Belongs to the AAA ATPase family. (410 aa)    
Predicted Functional Partners:
psmA
20S proteasome, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.922
psmB
20S proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.922
LRC61
Predicted protease (Mov34 family).
  
 0.904
pan-2
26s proteasome, regulatory subunit (proteasome-activating nucleotidase); ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, where [...]
  
  
 
0.904
RRC67
Predicted protease (Mov34 family).
  
 0.904
rpl40e
50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.872
RCIX1595
Putative trypsin-like protease.
   
 0.805
RRC204
Putative trypsin-like protease.
   
 0.805
RRC480
Putative trypsin-like protease.
   
 0.805
tuf-1
Translation elongation factor 1, alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
  
 0.786
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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