STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpPPi-dependent 6-phosphofructokinase (PFK-A family); Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (345 aa)    
Predicted Functional Partners:
fbaA
Fructose-bisphosphate aldolase (class II).
  
 
 0.985
fbaB-1
Fructose-bisphosphate aldolase (class I).
    
 0.923
RRC413
Putative hexulose-6-phosphate isomerase.
    
 0.922
aroF
Putative 2-dehydro-3-deoxy-phosphoheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
    
 0.920
RCIX1492
OMPdecase domain-containing protein; Conserved hypothetical protein (orotidine 5'-phosphate decarboxylase domain/dimethylmenaquinone methyltransferase domain).
     
 0.916
pfkA
ATP-dependent 6-phosphofructokinase (PFK-A family).
  
  
 
0.908
gpi
Putative glucose-6-phosphate isomerase.
     
 0.902
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.840
pyk
Pyruvate kinase (pyruvate phosphotransferase); Identical to orf1 of fosmid clone 3D10mr4; Belongs to the pyruvate kinase family.
 
 
 0.820
rpl4p
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
  
 
 0.764
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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