STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acs-1acetyl-CoA synthetase (AMP-forming). (581 aa)    
Predicted Functional Partners:
paaJ
acetyl-CoA C-acetyltransferase (thiolase I).
  
 
 0.958
pdhC
Pyruvate dehydrogenase complex E2,dihydrolipoamide acetyltransferase.
  
 
 0.936
leuA-4
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.933
leuA-2
2-isopropylmalate synthase.
  
 
 0.933
porA-1
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.929
porA-2
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.929
porB-1
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.927
porB-2
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.927
acdB
Acetyl-coa synthetase (ADP-forming), beta subunit.
    
 0.924
cdhC
Carbon monoxide dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.
   
 
 0.923
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.