Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mcrGMethyl-coenzyme M reductase, gamma subunit. (252 aa)    
Predicted Functional Partners:
mcrB
Methyl-coenzyme M reductase, beta subunit.
 
 0.999
mcrD-1
Methyl-coenzyme M reductase, operon protein D.
 
 0.999
mcrC
Methyl-coenzyme M reductase, operon protein C.
 
 0.999
mcrA
Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
 
 0.999
mcrD-2
Methyl-coenzyme M reductase operon protein D.
 
 0.999
LRC166
ABC-type transport system, ATPase component.
  
 
  0.992
LRC527
ABC-type transport system, ATPase component.
 
 
  0.992
LRC174
Conserved hypothetical protein.
 
 
   0.950
mtrE
N(5)-methyltetrahydromethanopterin-coenzyme M methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
 
 
 0.938
LRC172
Conserved hypothetical protein.
 
 
 
 0.936
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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