| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RCIX747 | apt | RCIX747 | RCIX1545 | Putative purine biosynthesis protein (SAICAR synthetase family). | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.610 |
| RCIX747 | purB | RCIX747 | RCIX2420 | Putative purine biosynthesis protein (SAICAR synthetase family). | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.992 |
| RCIX747 | purD | RCIX747 | RCIX513 | Putative purine biosynthesis protein (SAICAR synthetase family). | Phosphoribosylamine-glycine ligase. | 0.995 |
| RCIX747 | purL | RCIX747 | LRC115 | Putative purine biosynthesis protein (SAICAR synthetase family). | Putative phosphoribosylformylglycinamidine synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] | 0.976 |
| RCIX747 | purO | RCIX747 | RCIX491 | Putative purine biosynthesis protein (SAICAR synthetase family). | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.626 |
| RCIX747 | purP | RCIX747 | RCIX2374 | Putative purine biosynthesis protein (SAICAR synthetase family). | Predicted 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.810 |
| apt | RCIX747 | RCIX1545 | RCIX747 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Putative purine biosynthesis protein (SAICAR synthetase family). | 0.610 |
| apt | hisF-1 | RCIX1545 | RCIX1928 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Imidazole glycerol phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | 0.844 |
| apt | hisF-2 | RCIX1545 | RCIX2038 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Imidazole glycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.844 |
| apt | hisH-1 | RCIX1545 | RCIX1927 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.814 |
| apt | hisH-2 | RCIX1545 | RCIX1980 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.814 |
| apt | purB | RCIX1545 | RCIX2420 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.987 |
| apt | purD | RCIX1545 | RCIX513 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Phosphoribosylamine-glycine ligase. | 0.546 |
| apt | purL | RCIX1545 | LRC115 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Putative phosphoribosylformylglycinamidine synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] | 0.586 |
| apt | purP | RCIX1545 | RCIX2374 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Predicted 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.913 |
| hisF-1 | apt | RCIX1928 | RCIX1545 | Imidazole glycerol phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.844 |
| hisF-1 | hisF-2 | RCIX1928 | RCIX2038 | Imidazole glycerol phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.906 |
| hisF-1 | hisH-1 | RCIX1928 | RCIX1927 | Imidazole glycerol phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisF-1 | hisH-2 | RCIX1928 | RCIX1980 | Imidazole glycerol phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisF-1 | purB | RCIX1928 | RCIX2420 | Imidazole glycerol phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.849 |
