Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
ilvD-1Dihydroxy-acid dehydratase. (576 aa)    
Predicted Functional Partners:
ilvC
Alpha-keto-beta-hydroxylacil reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.985
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.985
leuA-2
2-isopropylmalate synthase.
 
 
 0.947
ilvD-2
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
  
 
0.908
ilvN
Acetolactate synthase, small subunit.
 
 
 0.886
ilvB
Acetolactate synthase, large subunit.
 
 0.866
htpX
Zn-dependent chaperonin protease; Belongs to the peptidase M48B family.
  
 
 0.677
htpX-2
Putative peptidase (M48 family); Belongs to the peptidase M48B family.
  
 
 0.677
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
  
 0.672
pdc
Putative pyruvate decarboxylase; Similar to other TPP enzymes, such as pyruvate oxidase (Pox)(EC 1.2.3.3) and pyruvate dehydrogenase (Pdh) (EC 1.2.2.2).
 
 
 0.661
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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