| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RCIX747 | apt | RCIX747 | RCIX1545 | Putative purine biosynthesis protein (SAICAR synthetase family). | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.599 |
| RCIX747 | purA | RCIX747 | RCIX1751 | Putative purine biosynthesis protein (SAICAR synthetase family). | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.890 |
| RCIX747 | purB | RCIX747 | RCIX2420 | Putative purine biosynthesis protein (SAICAR synthetase family). | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.998 |
| RCIX747 | purD | RCIX747 | RCIX513 | Putative purine biosynthesis protein (SAICAR synthetase family). | Phosphoribosylamine-glycine ligase. | 0.998 |
| RCIX747 | purE | RCIX747 | RCIX236 | Putative purine biosynthesis protein (SAICAR synthetase family). | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.996 |
| RCIX747 | purF | RCIX747 | LRC233 | Putative purine biosynthesis protein (SAICAR synthetase family). | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.997 |
| RCIX747 | purL | RCIX747 | LRC115 | Putative purine biosynthesis protein (SAICAR synthetase family). | Putative phosphoribosylformylglycinamidine synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] | 0.995 |
| RCIX747 | purM | RCIX747 | RCIX1823 | Putative purine biosynthesis protein (SAICAR synthetase family). | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.997 |
| RCIX747 | purQ | RCIX747 | LRC114 | Putative purine biosynthesis protein (SAICAR synthetase family). | Putative phosphoribosylformylglycinamidine synthase, glutamine amidotransferase domain. | 0.995 |
| apt | RCIX747 | RCIX1545 | RCIX747 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Putative purine biosynthesis protein (SAICAR synthetase family). | 0.599 |
| apt | purA | RCIX1545 | RCIX1751 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.891 |
| apt | purB | RCIX1545 | RCIX2420 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.988 |
| apt | purD | RCIX1545 | RCIX513 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Phosphoribosylamine-glycine ligase. | 0.659 |
| apt | purE | RCIX1545 | RCIX236 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.619 |
| apt | purF | RCIX1545 | LRC233 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.722 |
| apt | purL | RCIX1545 | LRC115 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Putative phosphoribosylformylglycinamidine synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] | 0.587 |
| apt | purM | RCIX1545 | RCIX1823 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.701 |
| apt | purP | RCIX1545 | RCIX2374 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Predicted 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.914 |
| apt | purQ | RCIX1545 | LRC114 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Putative phosphoribosylformylglycinamidine synthase, glutamine amidotransferase domain. | 0.581 |
| purA | RCIX747 | RCIX1751 | RCIX747 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Putative purine biosynthesis protein (SAICAR synthetase family). | 0.890 |