Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RCIX2467Predicted peptidase (M48 family). (282 aa)    
Predicted Functional Partners:
RCIX1976
Signal transduction serine/threonine kinase.
  
 
 
 0.666
hcp
Prismane protein (hybrid cluster protein); Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
    
 
 0.655
LRC445
Putative chaperonin (DnaJ family), N-terminal fragment.
  
 
 0.605
dnaJ
Chaperonin Hsp40; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK an [...]
  
 
 0.605
RCIX1090
Predicted Zn-finger protein interacting with DnaK (DnaJ-like).
  
 
 0.605
RCIX1138
Predicted protein interacting with DnaK (DnaJ-like).
  
 
 0.605
RCIX2503
Hypothetical protein.
  
 
 0.605
dnaK
Chaperonin Hsp70; Acts as a chaperone.
  
 
 0.580
htpX
Zn-dependent chaperonin protease; Belongs to the peptidase M48B family.
 
 
 
 0.542
grpE
DnaK co-chaperonin (Hsp70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several ro [...]
  
  
 0.539
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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