Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
leuA-42-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (397 aa)    
Predicted Functional Partners:
leuB-2
2-isopropylmalate dehydrogenase.
 
 0.995
leuD-2
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 
 0.992
leuC-2
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.992
paaJ
acetyl-CoA C-acetyltransferase (thiolase I).
  
 
 0.942
acs-1
acetyl-CoA synthetase (AMP-forming).
  
 
 0.921
acs-2
Putative acetyl-CoA synthetase (AMP-forming).
  
 
 0.921
pdhC
Pyruvate dehydrogenase complex E2,dihydrolipoamide acetyltransferase.
   
 0.917
porA-1
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.914
porB-1
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.914
porB-2
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.914
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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