node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LRC238 | RRC498 | LRC238 | RRC498 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Hypothetical protein. | 0.598 |
LRC238 | cbiA-1 | LRC238 | RCIX2001 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.616 |
LRC238 | cbiA-2 | LRC238 | RCIX825 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.609 |
LRC238 | cbiB | LRC238 | RCIX2654 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.711 |
LRC238 | cobD | LRC238 | RCIX2655 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Putative L-threonine-O-3-phosphate decarboxylase. | 0.699 |
LRC238 | cobQ | LRC238 | RCIX2662 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.743 |
LRC238 | cobS | LRC238 | RCIX2652 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.734 |
LRC238 | hisC | LRC238 | RCIX2460 | Conserved hypothetical protein; Belongs to the UPF0284 family. | Histidinol-phosphate aminotransferase. | 0.573 |
RCIX826 | cbiB | RCIX826 | RCIX2654 | Hypothetical protein similar to adenosylcobinamide amidohydrolase (CbiZ, EC 3.5.1.90). | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.951 |
RCIX826 | cobD | RCIX826 | RCIX2655 | Hypothetical protein similar to adenosylcobinamide amidohydrolase (CbiZ, EC 3.5.1.90). | Putative L-threonine-O-3-phosphate decarboxylase. | 0.433 |
RCIX826 | cobQ | RCIX826 | RCIX2662 | Hypothetical protein similar to adenosylcobinamide amidohydrolase (CbiZ, EC 3.5.1.90). | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.937 |
RCIX826 | cobS | RCIX826 | RCIX2652 | Hypothetical protein similar to adenosylcobinamide amidohydrolase (CbiZ, EC 3.5.1.90). | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.445 |
RRC498 | LRC238 | RRC498 | LRC238 | Hypothetical protein. | Conserved hypothetical protein; Belongs to the UPF0284 family. | 0.598 |
RRC498 | cbiB | RRC498 | RCIX2654 | Hypothetical protein. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.423 |
RRC498 | cobD | RRC498 | RCIX2655 | Hypothetical protein. | Putative L-threonine-O-3-phosphate decarboxylase. | 0.439 |
RRC498 | cobQ | RRC498 | RCIX2662 | Hypothetical protein. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.634 |
RRC498 | cobS | RRC498 | RCIX2652 | Hypothetical protein. | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.617 |
RRC498 | hisC | RRC498 | RCIX2460 | Hypothetical protein. | Histidinol-phosphate aminotransferase. | 0.455 |
cbiA-1 | LRC238 | RCIX2001 | LRC238 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Conserved hypothetical protein; Belongs to the UPF0284 family. | 0.616 |
cbiA-1 | cbiB | RCIX2001 | RCIX2654 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.897 |