Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hmgA-23-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (428 aa)    
Predicted Functional Partners:
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 0.997
RCIX149
Conserved hypothetical protein; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 
 0.995
hmgA
3-hydroxy-3-methylglutaryl-coenzyme a reductase (hmg-coa reductase); Belongs to the HMG-CoA reductase family.
     
 
0.900
fni
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.865
RCIX1254
Putative polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
 
 
 0.715
menA-1
Putative 1,4-dihydroxy-2-naphthoate octaprenyltransferase.
   
 
 0.689
menA-2
Putative 1,4-dihydroxy-2-naphtoate octaprenyl transferase.
   
 
 0.689
RCIX1132
Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
 
 
 0.683
crtE
Putative farnesyltranstransferase; Belongs to the FPP/GGPP synthase family.
  
 
 0.662
cdc48-3
Cell division cycle protein 48.
    
 
 0.579
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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