| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LRC271 | RCIX415 | LRC271 | RCIX415 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative archaeosine tRNA-ribosyltransferase. | 0.826 |
| LRC271 | RCIX625 | LRC271 | RCIX625 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.654 |
| LRC271 | RRC339 | LRC271 | RRC339 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein. | 0.563 |
| LRC271 | nac | LRC271 | RCIX1024 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative transcription factor (alpha-NAC related); Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.777 |
| LRC271 | pfdB | LRC271 | RCIX2129 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Chaperonin cofactor prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.702 |
| LRC271 | pimT | LRC271 | RCIX1025 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative tRNA (1-methyladenosine) methyltransferase. | 0.511 |
| LRC271 | ribK | LRC271 | RCIX631 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.696 |
| LRC271 | tgt-2 | LRC271 | RCIX2688 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.461 |
| LRC271 | tiaS | LRC271 | RCIX1429 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.681 |
| RCIX415 | LRC271 | RCIX415 | LRC271 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.826 |
| RCIX415 | RCIX625 | RCIX415 | RCIX625 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.676 |
| RCIX415 | RRC339 | RCIX415 | RRC339 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein. | 0.702 |
| RCIX415 | nac | RCIX415 | RCIX1024 | Putative archaeosine tRNA-ribosyltransferase. | Putative transcription factor (alpha-NAC related); Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.897 |
| RCIX415 | pfdB | RCIX415 | RCIX2129 | Putative archaeosine tRNA-ribosyltransferase. | Chaperonin cofactor prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.697 |
| RCIX415 | pimT | RCIX415 | RCIX1025 | Putative archaeosine tRNA-ribosyltransferase. | Putative tRNA (1-methyladenosine) methyltransferase. | 0.676 |
| RCIX415 | recJ | RCIX415 | RCIX2102 | Putative archaeosine tRNA-ribosyltransferase. | Putative single-stranded DNA-specific exonuclease. | 0.791 |
| RCIX415 | ribK | RCIX415 | RCIX631 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.698 |
| RCIX415 | tgt-2 | RCIX415 | RCIX2688 | Putative archaeosine tRNA-ribosyltransferase. | Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.948 |
| RCIX415 | tiaS | RCIX415 | RCIX1429 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.725 |
| RCIX625 | LRC271 | RCIX625 | LRC271 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.654 |