Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase expression/formation protein (maturation factor); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)    
Predicted Functional Partners:
hypB
Hydrogenase expression/formation protein (maturation factor).
 
 
 0.989
hypE
Hydrogenase expression/formation protein (maturation factor).
 
  
 0.981
hypC
Hydrogenase expression/formation protein (maturation factor).
 
  
 0.975
hypD
Hydrogenase expression/formation protein (maturation factor).
 
  
 0.964
hypF
Putative hydrogenase expression/formation protein (maturation factor).
 
   
 0.944
vhtA
F420-nonreducing hydrogenase (membrane-bound),large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.927
frhA-1
Coenzyme F420-reducing hydrogenase, alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.926
frhA-2
Coenzyme F420-reducing hydrogenase, alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.924
mvhA-2
Coenzyme F420-non-reducing hydrogenase (methyl viologen-reducing hydrogenase), alpha subunit.
 
 
 0.922
mvhA-1
Coenzyme F420-non-reducing hydrogenase (methyl viologen-reducing hydrogenase), alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.921
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.