STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
frhD-2Coenzyme F420-reducing hydrogenase, delta subunit (maturation peptidase). (159 aa)    
Predicted Functional Partners:
RCIX557
Predicted oxidoreductase integral membrane component (CooM/NuoL-like).
 
   
 0.842
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
   
   0.624
frhA-1
Coenzyme F420-reducing hydrogenase, alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
  
 0.549
frhA-2
Coenzyme F420-reducing hydrogenase, alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
  
 0.543
hypA
Hydrogenase expression/formation protein (maturation factor); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.527
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
     0.523
frhG-1
Coenzyme F420-reducing hydrogenase, gamma subunit.
 
  
 0.508
frhG-2
Coenzyme F420-reducing hydrogenase, gamma subunit.
 
  
 0.504
mvhA-2
Coenzyme F420-non-reducing hydrogenase (methyl viologen-reducing hydrogenase), alpha subunit.
 
  
 0.502
mvhA-1
Coenzyme F420-non-reducing hydrogenase (methyl viologen-reducing hydrogenase), alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
  
 0.496
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.