| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LRC271 | RCIX415 | LRC271 | RCIX415 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative archaeosine tRNA-ribosyltransferase. | 0.753 |
| LRC271 | RCIX625 | LRC271 | RCIX625 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.651 |
| LRC271 | RCIX710 | LRC271 | RCIX710 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; Belongs to the UPF0200 family. | 0.425 |
| LRC271 | ef1b | LRC271 | RCIX1379 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Translation elongation factor 1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | 0.453 |
| LRC271 | ribK | LRC271 | RCIX631 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.696 |
| LRC271 | rpoE | LRC271 | RCIX2017 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | DNA-directed RNA polymerase, subunit E. | 0.409 |
| LRC271 | rpoE2 | LRC271 | RCIX624 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative DNA-directed RNA polymerase, subunit E2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. | 0.467 |
| LRC271 | tiaS | LRC271 | RCIX1429 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.681 |
| RCIX415 | LRC271 | RCIX415 | LRC271 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.753 |
| RCIX415 | RCIX625 | RCIX415 | RCIX625 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.677 |
| RCIX415 | RCIX710 | RCIX415 | RCIX710 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; Belongs to the UPF0200 family. | 0.438 |
| RCIX415 | coaD | RCIX415 | RCIX1100 | Putative archaeosine tRNA-ribosyltransferase. | Putative phosphopantetheine adenylyltransferase. | 0.549 |
| RCIX415 | ef1b | RCIX415 | RCIX1379 | Putative archaeosine tRNA-ribosyltransferase. | Translation elongation factor 1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | 0.435 |
| RCIX415 | ribK | RCIX415 | RCIX631 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.698 |
| RCIX415 | tiaS | RCIX415 | RCIX1429 | Putative archaeosine tRNA-ribosyltransferase. | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.721 |
| RCIX620 | RCIX625 | RCIX620 | RCIX625 | Predicted archaea-specific kinase (GHMP-like family). | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.692 |
| RCIX620 | ef1b | RCIX620 | RCIX1379 | Predicted archaea-specific kinase (GHMP-like family). | Translation elongation factor 1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | 0.474 |
| RCIX620 | ribK | RCIX620 | RCIX631 | Predicted archaea-specific kinase (GHMP-like family). | Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.469 |
| RCIX620 | rpoE2 | RCIX620 | RCIX624 | Predicted archaea-specific kinase (GHMP-like family). | Putative DNA-directed RNA polymerase, subunit E2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. | 0.502 |
| RCIX620 | tiaS | RCIX620 | RCIX1429 | Predicted archaea-specific kinase (GHMP-like family). | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.575 |