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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pol2bDNA-directed DNA polymerase D, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1134 aa)    
Predicted Functional Partners:
pol2a
DNA-directed DNA polymerase D, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
 
 
 
 0.987
pcn
Putative DNA polymerase sliding clamp (proliferating cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
 
 
 0.959
LRC57
Putative single-stranded DNA-specific exonuclease (RecJ-like).
 
     0.697
LRC292
Predicted 3-isopropylmalate dehydratase.
  
     0.681
rpl31e
50S ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family.
  
     0.669
RCIX2351
Conserved hypothetical protein.
  
     0.665
rps27ae
30S ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family.
  
     0.659
nac
Putative transcription factor (alpha-NAC related); Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.655
rpl26e
50S ribosomal protein L26E; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
  
     0.653
recJ
Putative single-stranded DNA-specific exonuclease.
 
     0.650
Your Current Organism:
Methanocella arvoryzae
NCBI taxonomy Id: 351160
Other names: M. arvoryzae MRE50, Methanocella arvoryzae MRE50, Methanocella arvoryzae str. MRE50, Methanocella arvoryzae strain MRE50, uncultured methanogenic archaeon RC-I, uncultured methanogenic archaeon Rice Cluster I
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