STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B8C2I2_THAPS3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (414 aa)    
Predicted Functional Partners:
LEU2
3-isopropylmalate dehydratase.
 
 0.987
DAD1
Probable dihydroxyacid dehydratase.
 
  
 0.979
B8BRI7_THAPS
Pyruvate carboxyltransferase domain-containing protein.
 
 0.972
B8C732_THAPS
2-isopropylmalate synthase.
 
 
 0.951
acnB
Aconitase hydratase 2.
  
 
 0.887
CSN1
Citrate synthase; Belongs to the citrate synthase family.
  
 0.846
B8BX37_THAPS
EF-hand domain-containing protein.
  
 
0.836
SCS1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 
 0.781
B8C663_THAPS
Uncharacterized protein; Belongs to the TPP enzyme family.
 
 0.768
trpAB
Tryptophane synthase.
  
  
 0.761
Your Current Organism:
Thalassiosira pseudonana
NCBI taxonomy Id: 35128
Other names: T. pseudonana
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