Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
Maqu_16632-methylaconitate cis-trans isomerase; TIGRFAM: putative AcnD-accessory protein PrpF; PFAM: protein of unknown function DUF453; KEGG: reu:Reut_A1811 protein of unknown function DUF453. (392 aa)    
Predicted Functional Partners:
Maqu_1664
2-methylcitrate dehydratase (trans-methylaconitate-forming); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 
 0.997
Maqu_1662
KEGG: csa:Csal_2419 2-methylcitrate dehydratase PrpD; TIGRFAM: 2-methylcitrate dehydratase; PFAM: MmgE/PrpD family protein.
  
 
 0.988
Maqu_3674
Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.981
prpB
Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
  
 0.934
Maqu_1859
Aconitase; PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: sde:Sde_1893 transcriptional regulator, XRE family; Belongs to the aconitase/IPM isomerase family.
    
 0.911
Maqu_1665
KEGG: hch:HCH_02711 citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family.
 
  
 0.896
Maqu_1667
Transcriptional regulator, GntR family; PFAM: regulatory protein GntR, HTH; GntR domain protein; KEGG: hch:HCH_02709 transcriptional regulator.
 
  
 0.837
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
   0.636
Maqu_1149
KEGG: hch:HCH_04750 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
  
 0.569
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
    0.438
Your Current Organism:
Marinobacter hydrocarbonoclasticus
NCBI taxonomy Id: 351348
Other names: M. hydrocarbonoclasticus VT8, Marinobacter aquaeolei VT8, Marinobacter aquaeolei str. VT8, Marinobacter aquaeolei strain VT8, Marinobacter hydrocarbonoclasticus VT8
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