Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gura_2802
Hypothetical protein. (224 aa)
Predicted Functional Partners:
Gura_2803
TIGRFAM: metal dependent phophohydrolase; PFAM: histidine kinase, HAMP region domain protein; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region.
0.790
Your Current Organism:
Geobacter uraniireducens
NCBI taxonomy Id: 351605 Other names: G. uraniireducens Rf4, Geobacter uraniireducens Rf4, Geobacter uraniireducens str. Rf4, Geobacter uraniireducens strain Rf4, Geobacter uraniumreducens JCM 13001
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 annotation
node2 annotation
score
Gura_2802
Gura_2803
Hypothetical protein.
TIGRFAM: metal dependent phophohydrolase; PFAM: histidine kinase, HAMP region domain protein; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region.
0.790
Gura_2803
Gura_2802
TIGRFAM: metal dependent phophohydrolase; PFAM: histidine kinase, HAMP region domain protein; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region.
Hypothetical protein.
0.790
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: