STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Acel_0158Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (273 aa)    
Predicted Functional Partners:
Acel_1042
PFAM: amidohydrolase; Amidohydrolase 3; KEGG: reu:Reut_C6231 hypothetical protein.
  
 
 0.924
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
 
 
 0.919
Acel_0203
KEGG: tfu:Tfu_2896 hypoxanthine phosphoribosyl transferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.640
Acel_0264
Adenosine deaminase; Catalyzes the deamination of aminodeoxyfutalosine (AFL) into futalosine (FL), a step in the biosynthesis of menaquinone (MK, vitamin K2). Is very poorly efficient on 1-(6-amino-9H-purin-9-yl)-1-deoxy-N- ethyl-beta-D-ribofuranuronamide (NECA), adenosine, 5'- methylthioadenosine, 5'-deoxyadenosine, 2'-deoxyadenosine, and AMP as substrate.
  
 
 0.630
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.608
Acel_0157
KEGG: tfu:Tfu_0369 hypothetical protein.
       0.547
Acel_1631
PFAM: protein of unknown function DUF182; KEGG: sma:SAV1536 xanthine dehydrogenase accessory factor.
   
 
  0.508
Acel_1642
Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; KEGG: sme:SMb20132 probable aldehyde oxidase and xanthine dehydrogenase family protein transmembrane.
     
  0.499
Acel_0156
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell; Belongs to the MscL family.
       0.470
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
  
    0.433
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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