STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Acel_0432KEGG: gka:GK1960 hypothetical protein. (306 aa)    
Predicted Functional Partners:
Acel_0433
Dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: ret:RHE_PC00044 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family.
       0.776
Acel_0434
Carbohydrate ABC transporter substrate-binding protein, CUT1 family; PFAM: extracellular solute-binding protein, family 1; KEGG: sco:SCO2231 putative maltose-binding protein; TC 3.A.1.1.-.
       0.757
Acel_1827
PFAM: O-methyltransferase, family 3; Methyltransferase type 11; KEGG: fra:Francci3_3834 O-methyltransferase, family 3.
  
  
 0.686
Acel_0431
KEGG: bha:BH0491 hypothetical protein.
       0.618
dop
Protein of unknown function DUF245 domain protein; Displays depupylase (DPUP) activity, removing conjugated Pup from target proteins; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins. Is also able to catalyze the deamidation of the C-terminal glutamine to glutamate in a variant of the prokaryotic ubiquitin-like protein Pup; however, since Pup from A.cellulolyticus possesses a C-terminal glutamate, this deamidase activity may be of no significance in vivo.
  
  
 0.581
pafA
Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
  
  
 0.581
Acel_0435
PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: oih:OB0775 sugar ABC transporter permease; TC 3.A.1.1.-.
       0.559
Acel_0429
PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sma:SAV5771 alcohol dehydrogenase.
 
    0.514
Acel_0436
PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: mlo:mlr7002 ABC transporter, permease protein; TC 3.A.1.1.-.
       0.455
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
    0.422
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
Server load: medium (78%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.