Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
Acel_0769FO synthase subunit 1 / FO synthase subunit 2; KEGG: fra:Francci3_0745 conserved hypothetical protein; TIGRFAM: conserved hypothetical protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (884 aa)    
Predicted Functional Partners:
Acel_0455
LPPG:FO 2-phospho-L-lactate transferase; TIGRFAM: LPPG; PFAM: protein of unknown function UPF0052 and CofD; KEGG: tfu:Tfu_2517 LPPG:Fo 2-phospho-L-lactate transferase.
 
  
 0.984
Acel_1962
Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: nitroreductase; protein of unknown function DUF129; KEGG: sco:SCO3037 putative oxidoreductase.
 
   
 0.844
fbiD
Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
 
   
 0.814
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.686
Acel_1646
TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: tfu:Tfu_0970 NADPH-dependent F420 reductase.
 
     0.646
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.637
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.636
Acel_1645
PFAM: luciferase family protein; KEGG: nfa:nfa26770 hypothetical protein.
 
  
 0.627
Acel_0988
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: tfu:Tfu_1043 ThiS, thiamine-biosynthesis.
  
    0.598
Acel_1833
Anti-sigma-factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: dvu:DVU1449 anti-anti-sigma factor, putative; Belongs to the anti-sigma-factor antagonist family.
 
    0.597
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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