Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
htpXHeat shock protein; PFAM: peptidase M48, Ste24p; KEGG: fra:Francci3_2230 peptidase M48, Ste24p; Metallo peptidase; MEROPS family M48B; Belongs to the peptidase M48B family. (320 aa)    
Predicted Functional Partners:
Acel_0953
KEGG: sma:SAV6002 hypothetical protein.
 
     0.945
Acel_0950
Phage shock protein A, PspA; PFAM: Snf7; PspA/IM30 family protein; KEGG: sco:SCO2168 putative phage shock protein A.
 
    0.886
Acel_0951
KEGG: fra:Francci3_2229 conserved hypothetical protein.
 
     0.880
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.595
Acel_0954
TIGRFAM: iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein; KEGG: nfa:nfa17050 hypothetical protein; Belongs to the HesB/IscA family.
  
  
 0.569
Acel_1400
PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: sma:SAV2394 hypothetical protein.
   
    0.541
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
   
 0.524
ftsH-2
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.524
Acel_1869
PFAM: peptidase M41; AAA ATPase, central domain protein; SMART: AAA ATPase; KEGG: fra:Francci3_3487 AAA ATPase, central region.
   
 0.491
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.464
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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