node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acel_1061 | hisA | Acel_1061 | Acel_1062 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | 0.999 |
Acel_1061 | hisB | Acel_1061 | Acel_1060 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: fra:Francci3_3025 imidazoleglycerol-phosphate dehydratase. | 0.999 |
Acel_1061 | hisC | Acel_1061 | Acel_1059 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: tfu:Tfu_1151 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
Acel_1061 | hisD | Acel_1061 | Acel_1058 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
Acel_1061 | hisF | Acel_1061 | Acel_1069 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
Acel_1061 | hisG | Acel_1061 | Acel_1270 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.971 |
Acel_1061 | hisI | Acel_1061 | Acel_1070 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.988 |
Acel_1061 | pat | Acel_1061 | Acel_0035 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.864 |
hisA | Acel_1061 | Acel_1062 | Acel_1061 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | 0.999 |
hisA | hisB | Acel_1062 | Acel_1060 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: fra:Francci3_3025 imidazoleglycerol-phosphate dehydratase. | 0.999 |
hisA | hisC | Acel_1062 | Acel_1059 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: tfu:Tfu_1151 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.991 |
hisA | hisD | Acel_1062 | Acel_1058 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisF | Acel_1062 | Acel_1069 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Acel_1062 | Acel_1270 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.977 |
hisA | hisI | Acel_1062 | Acel_1070 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | pat | Acel_1062 | Acel_0035 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.846 |
hisA | trpC | Acel_1062 | Acel_1073 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | PFAM: Indole-3-glycerol phosphate synthase; KEGG: tfu:Tfu_1164 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. | 0.958 |
hisA | trpD | Acel_1062 | Acel_0966 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.940 |
hisB | Acel_1061 | Acel_1060 | Acel_1061 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: fra:Francci3_3025 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: nfa:nfa18480 putative amidotransferase. | 0.999 |
hisB | hisA | Acel_1060 | Acel_1062 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: fra:Francci3_3025 imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sma:SAV6158 putative phosphoribosylformimino-5-aminoimidazol e carboxamide ribotide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | 0.999 |