Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Acel_1635PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mlr7936 diaminopropionate ammonia-lyase. (402 aa)    
Predicted Functional Partners:
Acel_1639
PFAM: Asp/Glu racemase; KEGG: pab:PAB2420 arylmalonate decarboxylase.
 
     0.822
Acel_1637
Purine hydroxylase delta subunit apoprotein; PFAM: ferredoxin; [2Fe-2S]-binding domain protein; KEGG: reu:Reut_A3075 ferredoxin:(2Fe-2S)-binding.
 
     0.796
Acel_1634
KEGG: mth:MTH1911 hypothetical protein.
  
    0.776
Acel_1633
PFAM: purine catabolism PurC domain protein; KEGG: mta:Moth_2125 transcriptional regulator, CdaR.
       0.773
Acel_1638
Carbon-monoxide dehydrogenase (acceptor); PFAM: molybdopterin dehydrogenase, FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: ape:APE2219 292aa long hypothetical nicotine dehydrogenase chain A.
  
    0.766
Acel_1636
PFAM: carbon monoxide dehydrogenase subunit G; KEGG: bpa:BPP0391 hypothetical protein.
       0.762
Acel_1078
PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: fra:Francci3_3013 glutamate synthase (ferredoxin).
  
 
 0.689
Acel_0433
Dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: ret:RHE_PC00044 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family.
  
 
 0.627
ilvD
Dihydroxyacid dehydratase; KEGG: nfa:nfa11740 putative phosphogluconate dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.627
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.598
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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