Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Acel_1976PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; KEGG: sma:SAV4613 putative ATP-dependent RNA helicase. (838 aa)    
Predicted Functional Partners:
Acel_1975
Anti-sigma-factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: fra:Francci3_4302 anti-sigma-factor antagonist (STAS) domain protein.
       0.596
Acel_1480
SMART: helicase c2; DEAD/DEAH box helicase domain protein; KEGG: mpa:MAP2431 DinG.
  
   
 0.528
Acel_2157
PFAM: single-stranded nucleic acid binding R3H domain protein; KEGG: sma:SAV4311 putative Jag-like protein.
  
   
 0.448
Acel_1974
Putative anti-sigma regulatory factor, serine/threonine protein kinase; KEGG: sma:SAV4615 anti-sigma factor.
       0.443
Acel_1560
RNA-binding protein (contains KH domain)-like protein; KEGG: fra:Francci3_3593 conserved hypothetical protein SC2E1.09; Belongs to the UPF0109 family.
  
   
 0.442
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.404
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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