Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Acel_2113PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; protein of unknown function DUF224, cysteine-rich region domain protein; KEGG: fra:Francci3_4350 protein of unknown function DUF224, cysteine-rich region. (683 aa)    
Predicted Functional Partners:
Acel_2118
Transcriptional regulator, MerR family; PFAM: regulatory protein, MerR; KEGG: sma:SAV4487 HspR protein.
 
     0.537
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
     
 0.505
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
     
 0.499
Acel_2114
Hypothetical protein.
       0.488
Acel_0684
PFAM: electron transfer flavoprotein beta-subunit; KEGG: fra:Francci3_3659 electron transfer flavoprotein beta-subunit.
  
 0.469
Acel_0685
PFAM: electron transfer flavoprotein beta-subunit; electron transfer flavoprotein, alpha subunit; KEGG: sco:SCO1081 putative electron transfer flavoprotein, alpha subunit.
 
  
 0.457
Acel_0727
PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit; KEGG: ade:Adeh_3660 NADH ubiquinone oxidoreductase, 20 kDa subunit.
  
  
 0.430
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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