Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Acel_2120PFAM: PfkB domain protein; KEGG: tfu:Tfu_0928 fructokinase; Belongs to the carbohydrate kinase PfkB family. (311 aa)    
Predicted Functional Partners:
Acel_0467
PFAM: sugar isomerase (SIS); KEGG: fra:Francci3_0753 conserved hypothetical protein.
  
 
 0.916
pfp
Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
  
 0.916
Acel_1125
PFAM: phosphoglucose isomerase (PGI); KEGG: tfu:Tfu_2004 glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 
 0.910
Acel_1363
PFAM: Glycosyl hydrolase family 32, N terminal domain protein; KEGG: rba:RB5832 hypothetical protein.
  
 
 0.910
Acel_1877
TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: sma:SAV3215 putative glycerol-inducible protein.
    
 0.907
xylA
Xylose isomerase; KEGG: sma:SAV7182 putative xylose isomerase; TIGRFAM: xylose isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the xylose isomerase family.
     
 0.905
Acel_2098
TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase, type I; KEGG: sma:SAV5051 putative mannose-6-phosphate isomerase.
    
 0.905
glmS
Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
     
  0.900
Acel_0556
Glutamine--fructose-6-phosphate transaminase; PFAM: sugar isomerase (SIS); KEGG: ccr:CC0444 SIS domain protein.
     
  0.900
Acel_1596
PFAM: aldo/keto reductase; KEGG: sco:SCO0349 oxidoreductase (secreted protein).
  
  
  0.830
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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