STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Csac_1966PFAM: heat shock protein DnaJ domain protein; Tetratricopeptide TPR_2 repeat protein. (191 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.990
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 
 0.947
Csac_1967
Hypothetical protein.
 
     0.944
Csac_1394
Hypothetical protein.
  
 0.909
Csac_2658
Hypothetical protein.
  
 0.909
Csac_1965
PFAM: peptidase M16 domain protein.
  
 
 0.879
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.848
Csac_3005
KEGG: chd:Calhy_2327 methyltransferase type 11.
  
 
 0.844
rplM
Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
 
 
 0.817
Csac_0759
PFAM: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; Rhodanese domain protein; pyridine nucleotide-disulfide oxidoreductase dimerisation region.
  
 
 0.795
Your Current Organism:
Caldicellulosiruptor saccharolyticus
NCBI taxonomy Id: 351627
Other names: C. saccharolyticus DSM 8903, Caldicellulosiruptor saccharolyticus DSM 8903, Caldicellulosiruptor saccharolyticus str. DSM 8903, Caldicellulosiruptor saccharolyticus strain DSM 8903
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